Carlisle pair Danny Livesey and midfielder Marc Bridge-Wilkinson have been ruled out for the rest of the season with injuries.
Defender Livesey has patella tendonitis - a disease in the tendon that causes inflammation in the knee.Striker Bridge Wilkinson is recovering from an operation to remove floating bone in his big toe.
"It doesn't look like Danny and Marc are going to make it with the rehab work that's needed." manager Greg Abbott told BBC Radio Cumbria.
"We've just got to roll our sleeves up and get on with it."